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The unseen risk in CHD logo
For U.S. Healthcare Professionals
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Risk of PAH in CHD

PAH is a severe and progressive disease1-3

  • PAH is caused by restricted flow through the pulmonary arteries, leading to increased PVR, and ultimately, right heart failure and death1
  • Some conditions may predispose patients to PAH, including CHD3
  • CHD may be diagnosed at birth but sometimes is not detected until childhood or adulthood4
Risk of PAH in CHD patients Risk of PAH in CHD patients
About 1 in 10 adult patients
with CHD may develop PAH5
Risk of PAH in CHD patients

PAH can develop any time after a CHD repair3

However, some factors put adult patients with CHD at increased risk of PAH6
Woman graphic

Women have a higher risk of developing PAH-CHD6

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People with atrial septal defects and ventricular septal defects may develop PAH6

Prevalence of PAH-CHD in Asian, Hispanic, and White patients in the REVEAL Registry7*†

22%
Asian
(n=22/100)
15%
Hispanic
(n=39/263)
10%
White
(n=217/2202)
*The prevalence of PAH-CHD in Black patients was 3.3% (n=13/393) and 6.8% (n=6/88) in patients who were categorized as other.7

Risk of mortality in patients with PAH-CHD8

  • In a retrospective study of 192 patients with PAH, 65% of patients with PAH after a CHD repair survived 10 years after diagnosis
  • The average age of patients after a CHD repair was 36 ± 17 years
Survival rates in patients with PAH after a CHD repair‡
PAH survival rates chart PAH survival rates chart
‡This Kaplan-Meier chart is focused on a clinical subgroup of patients with PAH after cardiac defect correction.8
Republished with permission from Oxford University Press. Current era survival of patients with pulmonary arterial hypertension associated with congenital heart disease: a comparison between clinical subgroups. Manes A et al. Eur Heart J. 2014;35(11):716-724; permission conveyed through Copyright Clearance Center, Inc.
Man standing

Screening for PAH earlier may help diagnose patients sooner9-11

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